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Organic Synthesis Information Resources: Reviews & Treatises

Databases, handbooks, and book series related to organic synthesis, including searching for information on specific reactions or more general information about functional groups, protecting groups, and name reactions.

Science of Synthesis

Science of Synthesis is the 5th edition of the Houben-Weyl Methods in Organic Chemistry reference book series. It is a highly organized and authoritative collection of reviews on organic and organometallic synthetic methods. Reviews contain full experimental procedures and background information. Its purpose is to provide a direct path through the mass of primary literature to the pertinent data on a comprehensive range of organic reactions. The base set (2000 to present) contains information on over 275,000 reactions and 30,000 experimental procedures for 2,700 different types of compounds. The content is full-text, structure, and reaction searchable.

The Houben-Weyl Electronic Backfile (1909 to 2003) is also included and provides immediate access to 146,000 product specific experimental procedures, 580,000 structures, and 700,000 references in all fields of synthetic organic chemistry - dating back to the early 1800s.  [Note: most of this backfile is in German.]

Important Reviews and Treatises

These resources contain lengthier essays on various type of reactions or transformations and often provide numerous references to the original article where the research was reported.

Other "Comprehensive" Works

Comprehensive Analytical Chemistry. 1959- . v.1-17, v.19-41, v.43-57
(Chem Ref 543.082 W69c)

Comprehensive Asymmetric Catalysis. 1999, 2004. 3 vols. 2 supplements
(Chem 541.395 C738 1999 / Chem 541.395 C738 2004 Suppl.)

Comprehensive Biological Catalysis. 1998 4 vols.
(Chem Ref 572.7 C738 1998)

Comprehensive Coordination Chemistry. 1987. 7 vols.
(Chem Ref 541.2242 C738)
Comprehensive Coordination Chemistry II. 2004. 10 vols.
(Chem Ref 541.2242 C738 2004)

Comprehensive Heterocyclic Chemistry. 1984. 8 vols.
(Chem Ref 547.59 C738)
Comprehensive Heterocyclic Chemistry II. 1996. 11 vols.
(Chem Ref 547.59 C7382 1996)

Comprehensive Inorganic Chemistry. 1973. 5 vols.
(Chem Ref 546 C738)

Comprehensive Medicinal Chemistry. 1990. 6 vols.
(PNHS 615.19 C738 1990)
Comprehensive Medicinal Chemistry II. 2007. 8 vols.
(PNHS Ref 615.19 C738 2007)

Comprehensive Natural Products Chemistry. 1999. 9 vols.
(PNHS Ref 547.7 C7375 1999)

Comprehensive Organic Chemistry. 1979. 6 vols.
(Chem Ref 547 C738)

Comprehensive Organometallic Chemistry. 1982. 9 vols.
(Chem 547.05 C738)
Comprehensive Organometallic Chemistry II
. 1995. 14 vols.
(Chem Ref 547.05 C7381 1995)

Comprehensive Organometallic Chemistry III
.  2007.  13 vols.
(Chem Ref 547.05 C7381 1995)

Comprehensive Supramolecular Chemistry. 1996. 11 vols.
(Chem Ref 547.05 C738 1996)


Comprehensive Toxicology. 1st ed. 1997. 14 vols.
(PNHS Ref 615.9 C738 1997)
Comprehensive Toxicology. 2nd ed. 2010. 14 vols.